
In September 1693, at the height of his fame, Isaac Newton wrote two letters accusing his friends Samuel Pepys and John Locke of conspiring against him — including the line "twere better if you were dead." The article reconstructs the episode, examines the two leading explanations (the collapse of his friendship with Nicolas Fatio de Duillier, and chronic mercury poisoning from decades of alchemical work), and traces Newton's recovery and his subsequent transformation into England's most effective counterfeiter hunter.

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