Hantavirus Global Situational Briefing — May 17, 2026

ECDC added one inconclusive case on May 16, lifting the cluster total to 11. MV Hondius is due at Rotterdam tomorrow morning — 23 prefabricated quarantine cabins are in place on the dock. The British passenger hospitalized in the Netherlands has recovered and been cleared to travel home. Oceanwide Expeditions has not yet published its schedule decision, which the company said would come by the end of Sunday. The French ECMO patient at Hôpital Bichat remains critically ill with no change since the May 13 update.

This briefing covers the delta window May 16 00:50 UTC → May 17 00:00 UTC.

MV Hondius nears Rotterdam with 23 quarantine cabins waiting on the dock

On Friday, May 15, Dutch authorities erected 23 prefabricated quarantine cabins on the Rotterdam dockside in preparation for the ship's arrival. 1 Health Minister Sophie Hermans and Foreign Minister Tom Berendsen co-signed a letter to the Tweede Kamer formally designating Rotterdam as the Netherlands' national handling port for infectious-disease shipping cases. 1 2 Whether the cabins will also serve as the site for the complete mandatory 42-day isolation period has not yet been decided.

MV Hondius is expected to dock at Rotterdam on Monday morning, May 18. 3 There are 27 people aboard: 25 crew members and 2 RIVM (Netherlands Institute for Public Health and the Environment) medical staff. None are displaying hantavirus symptoms. 1 The ship also carries the body of a German passenger who died on board on May 2. Disembarkation will proceed in a staggered sequence per the Oceanwide protocol. 3

The 23 international crew members include 17 Filipinos, 4 Ukrainians, 1 Russian, and 1 Polish national. 1 Four Dutch nationals will complete quarantine at home. RIVM recommended that all 17 Filipino crew members remain in the Netherlands for their full six-week quarantine period, citing limited capacity for quarantine enforcement and medical care in the Philippines. 1 The Philippine Department of Migrant Workers confirmed that all 38 Filipino nationals associated with the Hondius have tested negative. Secretary Hans Leo Cacdac stated: "They all tested negative. We don't know anyone who is symptomatic at this stage." 1

Ship decontamination will be carried out by a specialized external contractor operating under RIVM and WHO guidelines. Cleaning staff will use PPE and are not required to enter quarantine afterward. 1 The Rotterdam-Rijnmond regional health service (GGD) confirmed it will test all crew and medical personnel upon arrival. 1

MV Hondius at sea with tugboats, May 10, 2026

Image from: Rotterdam Erects Quarantine Cabins for Hondius Crew — TechTimes

Separately, the British passenger from MV Hondius who was hospitalized in the Netherlands with hantavirus has recovered sufficiently to be cleared for travel to the United Kingdom, per the May 16 ministerial letter to parliament. 4

Oceanwide Expeditions schedule decision still pending. The company told the Associated Press on May 13 that it expected clarity on future MV Hondius sailings "by the end of this week" — Sunday, May 17. 5 No new press update has been published as of this writing; the most recent release remains the May 13 statement. 6 The May 29 Arctic cruise departing from Keflavik, Iceland remains listed on the Oceanwide website with unconfirmed status.

Case count rises to 11; French ECMO patient and Spain patient status unchanged

ECDC updated its Andes hantavirus outbreak page on May 16, reporting a total of 11 cases: 8 laboratory-confirmed, 2 probable, and 1 inconclusive. 7 The single addition since the May 13 baseline is one inconclusive case awaiting further laboratory investigation. No new confirmed cases or deaths have been reported; the death toll remains at 3. ECDC's risk assessment for the EU/EEA general population is unchanged: very low. 7

The French patient — a 65-year-old woman — remains on ECMO (extracorporeal membrane oxygenation) in the ICU at Hôpital Bichat in Paris. Dr. Xavier Lescure (Bichat) described her condition as a "severe form with life-threatening lung and heart complications." 8 No clinical update has been published since the May 13 PBS/AP report. The France Info live update page that previously tracked Pasteur Institute and Bichat Hospital communications now returns a 404 error; no replacement source has been identified.

The Spanish patient — a 70-year-old male — is being treated in the UATAN high-isolation unit at the Hospital Central de la Defensa Gómez Ulla in Madrid. His positive ANDV result was confirmed on May 11, and his condition has been described as stable and asymptomatic. 7 The isolation milestone expected around May 17–18 had not yet been formally announced within the monitoring window.

WHO DON-602 has not been published. The most recent WHO Disease Outbreak News is DON-601, dated May 13, 2026. 9 CDC reports zero confirmed US hantavirus cases and maintains its Emergency Operations Center at Level 3 activation; its situation page has been unchanged since May 12. 10 ECDC CDTR Week 21 (covering May 16–22) has not yet been published; the most recent Communicable Disease Threats Report is Week 20 (May 13). 11

Americas and US: Washington State's first Sin Nombre case of 2026; 41 under federal monitoring

Washington State Department of Health announced two separate hantavirus investigations on May 15. 12

The first concerns Andes virus exposure monitoring: 7 Washington residents are linked to the MV Hondius cruise ship outbreak. Four are in King County (3 from international flight exposure, 1 cruise passenger, and 1 additional low-risk flight contact identified on May 15), and 2 are in Eastern Washington. All are currently asymptomatic and under the 42-day monitoring protocol. 12 13 Public Health – Seattle & King County stated: "Currently, no one in King County has symptoms of Andes type of hantavirus and there are no cases of the Andes type virus in King County." 12

The second is entirely unrelated to the cruise ship: the Chelan-Douglas Health District confirmed the first Sin Nombre virus hantavirus pulmonary syndrome (HPS) case in Washington State in 2026. Sin Nombre is carried by deer mice and does not spread person-to-person; Washington typically records 1–5 such cases per year. 12 DOH assessed overall public risk as very low: "The risk of contracting any strain of hantavirus remains very low." 12

At the federal level, the CDC is monitoring 41 people across 12 states: Arizona, California, Georgia, Kansas, Maryland, Minnesota, Nebraska, New Jersey, Texas, Utah, Virginia, and Washington — all with zero confirmed hantavirus cases as of May 15. 14 Dr. Stephen Kornfeld — the Oregon oncologist who provided medical care to passengers aboard MV Hondius and had initially returned a "faintly positive" nasal swab — tested negative on confirmatory PCR and was moved from the University of Nebraska Medical Center biocontainment unit to a standard National Quarantine Unit on May 14. 14 All 16 passengers at the Nebraska quarantine facility are asymptomatic. HantaTracker records 21 US HPS cases year-to-date under CDC National Notifiable Disease Surveillance System reporting through MMWR Week 18 — all Sin Nombre strain, none ANDV. 15

Gloved hand holding a cryogenic vial labeled HANTA

Image from: DF fica em alerta após casos suspeitos de hantavírus — Correio Braziliense

Brazil's Distrito Federal has 3 suspect hantavirus cases under epidemiological investigation as of May 16. All had symptom onset in April 2026; 2 are DF residents and 1 is from another state. No laboratory confirmation has been obtained. The Secretaria de Estado de Saúde do DF (SES-DF) stated: "Atualmente, há três casos suspeitos em investigação epidemiológica, todos com início dos sintomas no mês de abril." 16 ("Currently, there are three suspected cases under epidemiological investigation, all with symptom onset in April.") The last confirmed hantavirus cases in DF were in 2022. 16 Nationwide, Brazil's cumulative data from 2013 through May 11, 2026 records 860 cases and 341 deaths; 7 cases have been confirmed in 2026 across Minas Gerais, Paraná, Santa Catarina, and Rio Grande do Sul, with one death — a 46-year-old man from Minas Gerais confirmed posthumously with a three-month diagnostic delay. 17

Argentina BEN SE18 has not yet been released; it is expected around May 19. The most recent bulletin — SE17 — holds the 2025–26 season at 102 confirmed cases and 32 deaths. Chile's national count remains at 39 cases and 13 deaths through early May; no new MINSAL hantavirus bulletin was identified in the monitoring window. Korea's KDCA website continues to return HTTP 400 errors (Day 8+); Chungnam Province announced strengthened HCPS (Hantavirus Cardiopulmonary Syndrome) surveillance on May 14 in response to the cruise outbreak, but no domestic HFRS (hemorrhagic fever with renal syndrome) case data has been obtained within the current visibility range. 18 China's NHC infectious disease surveillance page also remains inaccessible.

Research pipeline: Traws Pharma Q1 2026; no new genomic sequences or preprints

Traws Pharma (NASDAQ: TRAW) filed its Q1 2026 10-Q and 8-K with the SEC on May 15, confirming an active hantavirus antiviral program. 19 20 Key figures:

Metric	Q1 2026	Q1 2025
Net loss	$7.107M ($0.53/share)	—
R&D expenses	$4.912M	$2.506M
G&A expenses	$2.034M	$2.754M
Cash and equivalents	$3.133M	$3.820M (Dec 2025)

The 96% year-over-year increase in R&D spending reflects antiviral clinical trial milestone payments. 20 A $60 million PIPE (private investment in public equity) closed April 15 with $10 million received upfront and up to approximately $50 million available through milestone-based three-year warrants at $1.673 per share — extending the cash runway into Q1 2027. 21 The hantavirus program is listed as a pipeline priority; no clinical compound name or development timeline has been disclosed. The company's lead asset, tivoxavir marboxil (TXM) — an influenza antiviral — is in Phase I bridging study in Australia, with a UK human challenge trial planned for Q2 2026; a US FDA clinical hold on the TXM Investigational New Drug application remains unresolved and is targeted for resolution by year-end 2026. 20

The Pathoplexus ANDV database holds at 505 sequences, unchanged from the May 13 baseline; the five most recent entries (Netherlands ×2, Switzerland ×1, South Africa ×2) were released May 10–12. 22 No new hantavirus papers or preprints were published on PubMed, bioRxiv, or medRxiv in the monitoring window. NOAA's Climate Prediction Center maintains its El Niño Watch, with an 82% probability of El Niño onset by May–July 2026 and 96% through December 2026–February 2027; the Niño-3.4 index stands at +0.4°C. 23 El Niño conditions have historically elevated rodent populations across the Southern Cone, a recognized precursor to increased HPS incidence. The next NOAA ENSO update is scheduled for June 11.

Watchlist for May 18–22

MV Hondius Rotterdam arrival (Monday May 18 morning): GGD crew PCR testing outcomes; final quarantine placement for 17 Filipino crew members; decontamination commencement.
Oceanwide Expeditions schedule decision: Overdue as of Sunday evening May 17. May 29 Keflavik departure still listed; cancellation or confirmation expected.
French ECMO patient at Hôpital Bichat: Clinical trajectory remains the key variable. No update since May 13; primary French source (France Info Pasteur live page) currently offline.
Spain Gómez Ulla isolation milestone: The ~May 17–18 assessment for the stable Spanish patient had not been formally announced within the monitoring window.
Argentina BEN SE18: Expected approximately May 19.
Illinois Winnebago County CDC confirmatory result: Expected approximately May 22; would represent the first domestically acquired hantavirus case confirmed in Illinois since prior to 2026.

Briefing covers May 16 00:50 UTC → May 17 00:00 UTC. Previous edition: Hantavirus Global Situational Briefing — May 16, 2026. Next scheduled publication: May 18, 2026.

Cover image: AI-generated.