
美国一项名为「多基因风险评分」的新型基因技术,能预测你未来患心脏病、糖尿病的概率。但当这份风险报告送到雇主面前,2008 年制定的联邦基因歧视法已无力保护你。本期精选《纽约时报》深度报道,附完整中英对照译文、10 个核心词汇及两段长难句语法拆解。

| 单词 / 短语 | 音标 | 词性 | 中文释义 | 语境说明 |
|---|---|---|---|---|
| polygenic risk score | /ˌpɒliˈdʒenɪk rɪsk skɔː/ | n. phr. | 多基因风险评分 | 通过分析基因组中多个变异位点,综合估算患病概率的技术,是本文核心概念 |
| accommodate | /əˈkɒmədeɪt/ | v. | 为……提供便利;适应 | accommodation(名词形式)在法律语境中指「合理便利措施」,如调岗、减压,是美国残疾人法中的关键术语 |
| discrimination | /dɪˌskrɪmɪˈneɪʃn/ | n. | 歧视;区别对待 | employment discrimination(就业歧视)是贯穿本文的法律主题 |
| compel | /kəmˈpel/ | v. | 强制;迫使 | 文中指「法律是否强制要求」雇主采取某种行动,与 require 相比语气更强 |
| mitigate | /ˈmɪtɪɡeɪt/ | v. | 减轻;缓和 | mitigate a person's future health risk,减轻未来健康风险 |
| genomic | /dʒɪˈnɒmɪk/ | adj. | 基因组的 | genomic tools 指基因组层面的检测与分析工具,是精准医疗的基础 |
| lag | /læɡ/ | n./v. | 滞后;落后 | legal lag,法律滞后,指法律更新速度跟不上技术发展 |
| monogenic | /ˌmɒnəˈdʒenɪk/ | adj. | 单基因的 | 与 polygenic 相对,指由单一基因突变引发的疾病类型 |
| variant | /ˈveərɪənt/ | n. | 变异(位点);变体 | gene variant,基因变异位点,是多基因风险评分扫描的基本单位 |
| bioethics | /ˌbaɪəʊˈeθɪks/ | n. | 生命伦理学 | 研究医疗、生物技术中道德问题的学科,文中用于描述 Cohen 教授的专业方向 |
While the Genetic Information Nondiscrimination Act of 2008, or GINA, protects workers from being fired over their genetic test results, and the Americans With Disabilities Act protects those with active disabilities, neither law compels an employer to provide accommodations to help mitigate a person's future health risk.
If a monogenic test is like finding one severed wire that cuts off sound to a speaker, a polygenic risk score is like a soundboard, with dozens of switches that can combine to produce a dangerous frequency.
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