Hantavirus Global Situational Briefing — May 19, 2026

MV Hondius completed its long journey back to Rotterdam on May 18, formally closing the shipboard phase of the most unusual Andes hantavirus cluster in recorded history. All 27 people on board — 25 crew and 2 medical personnel — are now under Dutch quarantine. The Philippines' Department of Migrant Workers confirmed earlier in the week that all 38 Filipino seafarers tested negative; they remain in mobile-home quarantine units in the Rotterdam area for the full 42-day monitoring window1. Two Dutch crew members are under home quarantine. The ship is undergoing decontamination, and Oceanwide Expeditions says it can resume voyages next month if it passes a public-health inspection2.

The official tally from ECDC as of May 17 stands at 12 cases — 9 laboratory-confirmed, 2 probable, 1 inconclusive — with 3 deaths and a case fatality ratio of roughly 25%3. WHO DON-602, expected to document the Rotterdam arrival and updated counts, has not yet been published as of this briefing.

The French patient: still on ECMO

The most acute clinical concern remains the 65-year-old French woman at Hôpital Bichat in Paris. She was placed on extracorporeal membrane oxygenation (ECMO) after developing severe pulmonary and cardiac failure — a presentation consistent with Hantavirus Pulmonary Syndrome at its most critical. Her doctors describe her status as "the final stage of supportive care"4. The French prime minister, speaking alongside emergency ministry meetings convened on May 18, said the situation remains under control. Institut Pasteur sequencing has confirmed there is no dangerous new variant.

Spain: favorable recovery

The 70-year-old Spanish patient at Gómez Ulla Central Defence Hospital in Madrid is "recovering favorably" while still in isolation5. The remaining 13 Spanish evacuees tested negative.

Canada: first lab-confirmed case

The Public Health Agency of Canada confirmed on May 17 that a Yukon resident in their 70s has a laboratory-confirmed Andes hantavirus infection — Canada's first in this cluster. The person had presented with mild symptoms (fever, headache) on May 14 and was given a presumptive positive result on May 16; the National Microbiology Laboratory confirmed it the following day6 7. The patient is isolating in Victoria, British Columbia; their travel partner tested negative. This brings the confirmed Canadian count to one and brings ECDC's total to 12.

US: Illinois case ruled out

The Illinois Department of Public Health announced that CDC's confirmatory testing returned a negative result for the Winnebago County resident who had been under investigation since May 12. The case, which was unrelated to the MV Hondius outbreak, is now closed8. CDC continues to monitor approximately 41 people across 12 states — Arizona, California, Georgia, Kansas, Maryland, Minnesota, Nebraska, New Jersey, Texas, Utah, Virginia, and Washington — through June 22, with zero confirmed US Andes cases. Washington State's first 2026 Sin Nombre hantavirus HPS case (Chelan-Douglas County) remains a separate endemic-circuit event.

Bolivia: 4 Andes cases at the Argentine border

A previously unreported regional development: health authorities in Bolivia's Tarija department have confirmed 4 hantavirus cases in municipalities bordering Argentina, with sanitary protocols activated in border zones9. Bolivia's 2026 national cumulative total appears to be at least 18 cases. This is distinct from the Hondius cluster and represents Andes-strain endemic transmission in the southern altiplano, an area historically underreported.

Americas endemic scorecard

Country	Cases (season)	Deaths	CFR	Notes
Argentina	102	32	31.4%	SE17 (through May 12); SE18 BEN expected today
Chile	41	14	34.1%	Aysén cold-season alert
Bolivia	≥18 (4 Tarija)	—	—	New border-zone alert
Brazil	≥8 (2026)	2	—	Distrito Federal suspects under evaluation

Argentina's SE18 Boletín Epidemiológico Nacional is expected today10. ANLIS Malbrán researchers remain on-site in Ushuaia investigating the rodent-exposure source linked to the Hondius cluster's origin.

ECDC and WHO: risk levels unchanged

ECDC's Week 20 CDTR (published for the period May 9–15) confirms the European hantavirus risk assessment for the Andes cluster remains very low, given that Andes virus's natural rodent reservoir does not exist in Europe11. Week 21 has not yet been published. WHO's global risk assessment remains low for the general public; ship-board contacts have been rated at medium since May 13's DON-601. DON-602 is anticipated to confirm the Rotterdam landing, the Canada confirmation, and the Winnebago County closure, but has not been released as of this briefing.

Genomics note

Pathoplexus holds 509 ANDV sequences as of May 18. Pasteur's Institut confirmed no new dangerous variant; all sequenced cases from the Hondius cluster show ≤1 SNP divergence, consistent with a single zoonotic spillover event on the voyage followed by human-to-human transmission12.

Pipeline: Traws Pharma regulatory update

Traws Pharma (NASDAQ: TRAW) is advancing tivoxavir marboxil (TXM) toward a Q2 2026 human challenge trial in the UK for influenza prophylaxis — with a parallel hantavirus antiviral program in the pipeline — while working to resolve an FDA clinical hold on its US IND13. The $60M PIPE closed April 15; cash runway extends to Q1 2027.

What to watch next

WHO DON-602: Will document Rotterdam arrival, Canada confirmation, updated cluster total, and any change in the risk matrix for residual high-risk contacts
ECDC CDTR Week 21: Expected to cover the week of May 16–22; watch for final Rotterdam crew PCR results
Argentina BEN SE18: Due today; will show whether the southern-cone cold-season is accelerating case accumulation
France ECMO patient: Status remains the cluster's most critical clinical thread — discharge or deterioration will be the week's headline if it moves
Spain patient: Discharge expected imminently if recovery continues on current trajectory
Bolivia surveillance: Tarija border-zone activity warrants close monitoring given proximity to Argentina's Andes-strain endemic region